Lab Overview

Welcome to the Murray Lab

Research in the lab, led by John D. Murray, focuses on investigating the dynamics and function of neural circuits, and their dysfunction in psychiatric and neurological disorders. To investigate these issues, we develop modeling, theoretical, and data-analytic approaches to systems neuroscience, in close collaboration with experimentalists. We build biophysically-based neural circuit models that span levels of scale and complexity, ranging from detailed microcircuitry supporting cognitive function, to large-scale brain dynamics. Furthermore, we leverage computational insights from models to advance the study of disorders such as schizophrenia, in a framework for Computational Psychiatry.

Lab News

  • Norman Lam (Physics PhD student) has been awarded a Graduate Scholarship from the the National Sciences and Engineering Research Council (NSERC) of Canada. Congratulations, Norman!
  • The lab has been awarded its first R01 grant from the National Institute of Mental Health.
  • Special Issue in Biological Psychiatry on "Cortical Excitation-Inhibition Balance and Dysfunction in Psychiatric Disorders" (Edited by Alan Anticevic and John Murray)    [Link] 

Upcoming Events

  • Oct 11: John will give a talk at the WPA World Congress of Psychiatry in Berlin    [Link]
  • Nov 12: John will give a talk at the annual SfN meeting in a Minisymposium on "Computational Psychiatry: Multiscale Models of Mental Illnesses"    [Link] 
  • Nov 11-15: The Murray Lab will present multiple posters at the annual SfN meeting in Washington DC. Check them out!     [Murat Demirtas]    [Markus Helmer]    [Josh Burt]    [Norman Lam]    [Max Shinn]

Principal Investigator

John D Murray, PhD

Assistant Professor of Psychiatry

Recent publications
  • Murray JD*, Jaramillo JH*, Wang X-J (2017) (* denotes equal contribution)   
    Working memory and decision making in a fronto-parietal circuit model.   
    BioRxiv 10.1101/104802   
    [DOI: 10.1101/104802]  
  • Lam NH, Borduqui T, Hallak J, Roque AC, Anticevic A, Krystal JH, Wang X-J, Murray JD (2017)  
    Effects of altered excitation-inhibition balance on decision making in a cortical circuit model.  
    BioRxiv 10.1101/100347  
    [DOI: 10.1101/100347] 
  • Murray JD, Bernacchia A, Roy NA, Constantinidis C, Romo R, Wang X-J (2017)  
    Stable population coding for working memory coexists with heterogeneous neural dynamics in prefrontal cortex. 
    Proceedings of the National Academy of Sciences 114:394  
    [DOI: 10.1073/pnas.1619449114]